Container Closure Integrity Testing (CCIT)
Understanding CCIT
Container Closure Integrity Testing (CCIT) is the process of evaluating whether a container and its closure system effectively maintain a sterile barrier. It ensures the package is sealed against the ingress or leakage of gases, moisture, pressure, or other contaminants that may compromise product stability, potency, or safety.
Consumer and patient safety is the fundamental reason behind stringent regulations, quality control, and assurance protocols. A crucial element of product safety begins with the primary packaging and its ability to preserve sterility through a reliable container closure system.
What does Container Closure Integrity Testing involve?
At Gasporox, our CCIT solutions are built on Headspace Analysis (HSA) using Tunable Diode Laser Absorption Spectroscopy (TDLAS) technology. This technique measures the gas content and concentration in the headspace; the empty space between the product and the container closure.
By analysing the headspace gas composition, not only can current leaks be detected, but it is also possible to identify historical leaks that have resealed, as these events often leave behind changes in the headspace gas profile.
Applications Across Industries and Packaging Formats
CCIT is essential in pharmaceutical manufacturing for in-line and at-line quality control. It also plays a significant role in research and development settings, where product sterility and stability are tested during formulation and packaging development.
Our testing solutions are applicable across a broad range of packaging types and materials, including:
- Vials and Ampoules – tubular or moulded, clear or amber
- Pre-filled Syringes and injectors
- Large Volume Parenterals – such as IV bags or bottles
How does it work?
Gasporox’s CCIT technology is based on non-destructive headspace analysis using TDLAS, a precise optical spectroscopy method for gas detection.
In this method, laser diodes are finely tuned to the absorption wavelength of the target gas (e.g. oxygen (O₂), carbon dioxide (CO₂), or water vapour (H₂O)). As the laser passes through the headspace, specific gas molecules absorb portions of the light. The resulting reduction in light intensity is measured and directly correlates with the gas concentration inside the container.
This technique enables rapid, accurate, and non-invasive analysis of sealed containers without damaging the packaging or affecting the product inside.
Do you need Container Closure Integrity Testing in your quality control?
Why Choose Gasporox for Container Closure Integrity Testing?
Gasporox is a leader in laser-based inspection systems for non-invasive, non-destructive package integrity testing. Our CCIT technology provides unmatched precision, speed, and reliability, helping manufacturers ensure product safety, regulatory compliance, and process efficiency without sacrificing throughput, available as at-line or in-line solutions.